| Spanish slave traders of the early 16th | | | | including the Pilgrims, who were heading |
| Century were probably the first | | | | for the Hudson River, got blown |
| Europeans to interact with the native | | | | off-course and anchored in Provincetown |
| population of Florida.[4] The first | | | | Harbor before they settled at |
| documented encounter of Europeans with | | | | present-day Plymouth, Massachusetts, |
| Native Americans of the United States | | | | instead, during a harsh winter. In the |
| came with the first expedition of Juan | | | | autumn of 1621, they celebrated a |
| Ponce de León to Florida in 1513, | | | | three-day thanksgiving feast with the |
| although he encounted at least one | | | | native Wampanoag people, without whom |
| native that spoke Spanish. In 1521, he | | | | they would not have survived the winter |
| encountered the Calusa people during a | | | | of 1620. |
| failed colonization attempt in which | | | | The Great Migration continued into the |
| they drove off the Europeans. | | | | 1630s and 40s, creating many settlements |
| In 1526, Lucas Vásquez de Ayllón tried | | | | in New England and the Virginia colony. |
| to found a colony in what is now South | | | | Dutch colonization activities proceeded |
| Carolina, but for multiple reasons it | | | | in an overlapping terr Pequot War |
| failed after only a year. The remaining | | | | Meanwhile, Spanish and French |
| slaves of the colony revolted and fled | | | | colonization were also proceeding on |
| into the wilderness to live among the | | | | other areas of the continent. |
| Cofitachiqui people. | | | | Some European settlers used Native |
| The next encounter came with the members | | | | American contacts to further their |
| of the Narváez expedition from | | | | activities in the fur trade; others sold |
| 1528–1536. Álvar Núnez Cabeza de | | | | European technology to the natives, |
| Vaca wrote a detailed account of the | | | | including firearms which fueled tribal |
| failed expedition which includes | | | | wars. Peaceful coexistence was |
| descriptions of several Native American | | | | established in some times and places. |
| cultures he encountered from Florida, | | | | For example, the careful diplomacy of |
| the northern Gulf Coast, Texas, possibly | | | | William Pynchon facilitated the founding |
| New Mexico and Arizona, and northern | | | | of what would become Springfield, |
| Mexico. He described the behavior, | | | | Massachusetts in a desirable farming |
| living situation, dress, and food of the | | | | location close to the native Agawam |
| people he encountered as he wandered | | | | settlement. |
| from village to village. | | | | Struggles for economic and territorial |
| An expedition in 1539 headed by Fray | | | | dominance also continued to result in |
| Marcos de Niza went in search of The | | | | armed conflict. In some cases these |
| Seven Cities of Gold. They were guided | | | | latent conflicts resulted in escalating |
| by another survivor of the Narváez | | | | tensions, gradually followed by |
| expedition, Estevanico, who encountered | | | | escalating multi-party violence. In |
| the Zuni people in his wanderings. | | | | other cases sudden, relatively |
| Following de Niza in search of the | | | | unprovoked raids were conducted on |
| fabled cities was Francisco Vásquez de | | | | native and colonial settlements, which |
| Coronado from 140–1542. He had | | | | might involve arson, massacre, or |
| encounters with the Hopi and Zuni as | | | | kidnapping for slavery. |
| well as several other native groups in | | | | Pre-existing rivalries among both the |
| Arizona, New Mexico, Texas, Kansas, and | | | | Native American tribes and confederacies |
| Oklahoma. | | | | and the European nations led groups from |
| Also in 1539, the Hernando De Soto | | | | both continents to find war allies among |
| expedition traveled through the Southern | | | | the others against their traditional |
| United States from 1539–1542. This | | | | enemies. When transatlantic |
| expedition was responsible for | | | | civilizations clashed, better technology |
| introducing diseases into that region, | | | | (including firearms) and the epidemics |
| and also resulted in several battles | | | | decimating native populations gave |
| with various tribes. The expedition | | | | Europeans a substantial military |
| included a member of the failed Narváez | | | | advantage. |
| expedition of 1528 named Juan Ortiz who | | | | In 1637, the Pequot War erupted in the |
| lived among the Tocobaga people for | | | | Massachusetts and Plymouth colonies. |
| twelve years before being rescued by de | | | | Indian Wars in the English colonies |
| Soto. | | | | would continue on and off into the |
| Another encounter was the failed Roanoke | | | | American Revolution. |
| Colony led by Sir Walter Raleigh of | | | | In the early 1680s, Philadelphia was |
| England in 1584. At first, the local | | | | established by William Penn in the |
| tribes bartered with the colonists, but | | | | Delaware Valley, which was home to the |
| this was during a time of a severe | | | | Lenni-Lenape nation. Chief Tamanend |
| drought, and when the local tribes grew | | | | reputably took part in a peace treaty |
| more reluctant to trade, relations | | | | between the leaders of the Lenni-Lenape |
| deteriorated. The fate of the colonists | | | | nation and the leaders of the |
| is still a controversy. | | | | Pennsylvania colony held under a large |
| By 1578 there were about 350 European | | | | elm tree at Shakamaxon. |
| fishing vessels at Newfoundland and | | | | In the Spanish sphere, many of the |
| sailors began to trade metal implements | | | | Pueblo people harbored hostility toward |
| (particularly knives) for the natives' | | | | the Spanish, primarily due to their |
| well worn pelts. The French fur trade | | | | denigration and prohibition of the |
| was undertaken by Francis Grave (a | | | | traditional religion (the Spanish at the |
| merchant) and Chauvin (a captain) in | | | | time being staunchly and aggressively |
| 1599 when they acquired a monopoly from | | | | Catholic). The traditional economies of |
| Henry IV and their attempt to establish | | | | the pueblos were likewise disrupted when |
| a colony at the mouth of the Saguenay | | | | they were forced to labor on the |
| River was a direct result of their | | | | encomiendas of the colonists. However, |
| desire to profit from trading native fur | | | | the Spanish had introduced new farming |
| pelts for European goods. | | | | implements and provided some measure of |
| England attempted again to colonize, | | | | security against Navajo and Apache |
| first in 1606 with the Popham Colony in | | | | raiding parties. As a result, they lived |
| present-day Maine, and again in 1607 in | | | | in relative peace with the Spanish |
| Jamestown, Virginia. The latter became | | | | following the founding of the Northern |
| the first permanent English settlement | | | | New Mexican colony in 1598. In the |
| in the United States. The Popham Colony | | | | 1670s, however, drought swept the |
| interacted with the Abeneki tribe, but | | | | region, which not only caused famine |
| failed to establish cooperation. | | | | among the Pueblo, but also provoked |
| Jamestown's breakdown in relations with | | | | increased attacks from neighboring |
| the Paspahegh and Powhatan tribes | | | | hunter-gatherer tribes — attacks |
| resulted in the First Anglo–Powhatan | | | | against which Spanish soldiers were |
| War, which ended with the marriage of | | | | unable to defend. At the same time, |
| John Rolfe and Pocahontas. | | | | European-introduced diseases were |
| In 1610 a teenage Étienne Brulé was | | | | ravaging the natives, greatly decreasing |
| sent by Samuel de Champlain to live with | | | | their numbers. It has also been alleged |
| the Hurons for a year as a sort of | | | | that the introduction of these diseases |
| 'exchange student'. Champlian, in turn, | | | | was often exacerbated when soldiers |
| accepted the company of a Huron youth | | | | handed out blankets and other |
| named Savignon who accompanied him back | | | | humanitarian supplies carrying European |
| to France. The two cultures made a | | | | microorganisms.[citation needed] |
| successful rendezvous the next year and | | | | Unsatisfied with the protective powers |
| the young men returned to their | | | | of the Spanish crown, the Pueblo |
| respective groups to report their | | | | revolted in 1680. In 1692, Spanish |
| experiences. | | | | control was reasserted, but under much |
| In 1620, a group of English settlers, | | | | more lenient terms. |