| Spanish slave traders of the early 16th | | | | |
| Century were probably the first Europeans to | | | | In 1620, a group of English settlers, |
| interact with the native population of | | | | including the Pilgrims, who were heading for |
| Florida.[4] The first documented encounter of | | | | the Hudson River, got blown off-course and |
| Europeans with Native Americans of the United | | | | anchored in Provincetown Harbor before they |
| States came with the first expedition of Juan | | | | settled at present-day Plymouth, |
| Ponce de León to Florida in 1513, although | | | | Massachusetts, instead, during a harsh |
| he encounted at least one native that spoke | | | | winter. In the autumn of 1621, they |
| Spanish. In 1521, he encountered the Calusa | | | | celebrated a three-day thanksgiving feast |
| people during a failed colonization attempt | | | | with the native Wampanoag people, without |
| in which they drove off the Europeans. | | | | whom they would not have survived the winter |
| | | | of 1620. |
| In 1526, Lucas Vásquez de Ayllón tried | | | | |
| to found a colony in what is now South | | | | The Great Migration continued into the 1630s |
| Carolina, but for multiple reasons it failed | | | | and 40s, creating many settlements in New |
| after only a year. The remaining slaves of | | | | England and the Virginia colony. Dutch |
| the colony revolted and fled into the | | | | colonization activities proceeded in an |
| wilderness to live among the Cofitachiqui | | | | overlapping terr Pequot War Meanwhile, |
| people. | | | | Spanish and French colonization were also |
| | | | proceeding on other areas of the continent. |
| The next encounter came with the members of | | | | |
| the Narváez expedition from | | | | Some European settlers used Native American |
| 1528–1536. Ãlvar Núnez Cabeza de | | | | contacts to further their activities in the |
| Vaca wrote a detailed account of the failed | | | | fur trade; others sold European technology to |
| expedition which includes descriptions of | | | | the natives, including firearms which fueled |
| several Native American cultures he | | | | tribal wars. Peaceful coexistence was |
| encountered from Florida, the northern Gulf | | | | established in some times and places. For |
| Coast, Texas, possibly New Mexico and | | | | example, the careful diplomacy of William |
| Arizona, and northern Mexico. He described | | | | Pynchon facilitated the founding of what |
| the behavior, living situation, dress, and | | | | would become Springfield, Massachusetts in a |
| food of the people he encountered as he | | | | desirable farming location close to the |
| wandered from village to village. | | | | native Agawam settlement. |
| | | | |
| An expedition in 1539 headed by Fray Marcos | | | | Struggles for economic and territorial |
| de Niza went in search of The Seven Cities of | | | | dominance also continued to result in armed |
| Gold. They were guided by another survivor of | | | | conflict. In some cases these latent |
| the Narváez expedition, Estevanico, who | | | | conflicts resulted in escalating tensions, |
| encountered the Zuni people in his | | | | gradually followed by escalating multi-party |
| wanderings. Following de Niza in search of | | | | violence. In other cases sudden, relatively |
| the fabled cities was Francisco Vásquez de | | | | unprovoked raids were conducted on native and |
| Coronado from 140–1542. He had | | | | colonial settlements, which might involve |
| encounters with the Hopi and Zuni as well as | | | | arson, massacre, or kidnapping for slavery. |
| several other native groups in Arizona, New | | | | |
| Mexico, Texas, Kansas, and Oklahoma. | | | | Pre-existing rivalries among both the Native |
| | | | American tribes and confederacies and the |
| Also in 1539, the Hernando De Soto expedition | | | | European nations led groups from both |
| traveled through the Southern United States | | | | continents to find war allies among the |
| from 1539–1542. This expedition was | | | | others against their traditional enemies. |
| responsible for introducing diseases into | | | | When transatlantic civilizations clashed, |
| that region, and also resulted in several | | | | better technology (including firearms) and |
| battles with various tribes. The expedition | | | | the epidemics decimating native populations |
| included a member of the failed Narváez | | | | gave Europeans a substantial military |
| expedition of 1528 named Juan Ortiz who lived | | | | advantage. |
| among the Tocobaga people for twelve years | | | | |
| before being rescued by de Soto. | | | | In 1637, the Pequot War erupted in the |
| | | | Massachusetts and Plymouth colonies. Indian |
| Another encounter was the failed Roanoke | | | | Wars in the English colonies would continue |
| Colony led by Sir Walter Raleigh of England | | | | on and off into the American Revolution. |
| in 1584. At first, the local tribes bartered | | | | |
| with the colonists, but this was during a | | | | In the early 1680s, Philadelphia was |
| time of a severe drought, and when the local | | | | established by William Penn in the Delaware |
| tribes grew more reluctant to trade, | | | | Valley, which was home to the Lenni-Lenape |
| relations deteriorated. The fate of the | | | | nation. Chief Tamanend reputably took part in |
| colonists is still a controversy. | | | | a peace treaty between the leaders of the |
| | | | Lenni-Lenape nation and the leaders of the |
| By 1578 there were about 350 European fishing | | | | Pennsylvania colony held under a large elm |
| vessels at Newfoundland and sailors began to | | | | tree at Shakamaxon. |
| trade metal implements (particularly knives) | | | | |
| for the natives' well worn pelts. The French | | | | In the Spanish sphere, many of the Pueblo |
| fur trade was undertaken by Francis Grave (a | | | | people harbored hostility toward the Spanish, |
| merchant) and Chauvin (a captain) in 1599 | | | | primarily due to their denigration and |
| when they acquired a monopoly from Henry IV | | | | prohibition of the traditional religion (the |
| and their attempt to establish a colony at | | | | Spanish at the time being staunchly and |
| the mouth of the Saguenay River was a direct | | | | aggressively Catholic). The traditional |
| result of their desire to profit from trading | | | | economies of the pueblos were likewise |
| native fur pelts for European goods. | | | | disrupted when they were forced to labor on |
| | | | the encomiendas of the colonists. However, |
| England attempted again to colonize, first in | | | | the Spanish had introduced new farming |
| 1606 with the Popham Colony in present-day | | | | implements and provided some measure of |
| Maine, and again in 1607 in Jamestown, | | | | security against Navajo and Apache raiding |
| Virginia. The latter became the first | | | | parties. As a result, they lived in relative |
| permanent English settlement in the United | | | | peace with the Spanish following the founding |
| States. The Popham Colony interacted with the | | | | of the Northern New Mexican colony in 1598. |
| Abeneki tribe, but failed to establish | | | | In the 1670s, however, drought swept the |
| cooperation. Jamestown's breakdown in | | | | region, which not only caused famine among |
| relations with the Paspahegh and Powhatan | | | | the Pueblo, but also provoked increased |
| tribes resulted in the First | | | | attacks from neighboring hunter-gatherer |
| Anglo–Powhatan War, which ended with | | | | tribes — attacks against which Spanish |
| the marriage of John Rolfe and Pocahontas. | | | | soldiers were unable to defend. At the same |
| | | | time, European-introduced diseases were |
| In 1610 a teenage Étienne Brulé was | | | | ravaging the natives, greatly decreasing |
| sent by Samuel de Champlain to live with the | | | | their numbers. It has also been alleged that |
| Hurons for a year as a sort of 'exchange | | | | the introduction of these diseases was often |
| student'. Champlian, in turn, accepted the | | | | exacerbated when soldiers handed out blankets |
| company of a Huron youth named Savignon who | | | | and other humanitarian supplies carrying |
| accompanied him back to France. The two | | | | European microorganisms.[citation needed] |
| cultures made a successful rendezvous the | | | | Unsatisfied with the protective powers of the |
| next year and the young men returned to their | | | | Spanish crown, the Pueblo revolted in 1680. |
| respective groups to report their | | | | In 1692, Spanish control was reasserted, but |
| experiences. | | | | under much more lenient terms. |